Human Apoptosis Array Kit Reference List

Silencing of Pokemon Enhances Caspase-Dependent Apoptosis via Fas- and Mitochondria-Mediated Pathways in Hepatocellular Carcinoma Cells

Yu-Qin Zhang, Chuan-Xing Xiao, Bi-Yun Lin1, Ying Shi, Yun-Peng Liu, Jing-Jing Liu, Bayasi Guleng, Jian-Lin Ren

PLoS One. 2013 Jul 17;8(7):e68981

사용제품: Human Apoptosis Array Kit (ARY009)

Sample: Hepatocellular carcinoma (HCC) cell lysate

해당 논문은 HCC cell과 anti-cancer drug을 이용해서 cancer cell death의 기작을 확인하고자 human apoptosis array kit을 사용했습니다. 해당 제품을 통해서 어떤 apoptosis 관련 단백질들에 차이를 보이는지 확인할 수 있었으며, 과발현된 단백질들을 통해 extrinsic과 intrinsic 중 어떤 pathway를 통해 apoptosis가 일어났는지도 확인했습니다.

Bitter Melon (Momoridca charantia) Extract Inhibits Breast Cancer Cell Proliferation by Modulating Cell Cycle Regulatory Genes and Promotes Apoptosis

Ratna B. Ray, Amit Raychoudhuri, Robert Steele, and Pratibha Nerurkar

Cancer Res 2010;70:1925-1931

사용제품: Human Apoptosis Array kit (ARY009)

Sample: MCF-7 and MDA-MB-231 cell lysate

해당 논문은 비터멜론 추출물이 유방암세포의 cell cycle을 막고 apoptosis를 유발한다는 사실을 밝혔습니다. 이 때 비터멜론 추출물에 의해 어떤 apoptosis 관련 단백질들이 영향을 받는지 알아보기 위해서 apoptosis array kit을 사용했으며, array 결과를 토대로 비터멜론 추출물이 어떤 signaling을 통해 유방암세포에 영향을 주는지에 대한 이론을 제시할 수 있었습니다.

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1.Inhibition of vacuolar H+ ATPase enhances sensitivity to tamoxifen via up-regulation of CHOP in breast cancer cells

Hyeon-Ok Jin, Yun-Han Lee, Hyun-Ah Kim, Eun-Kyu Kim, Woo Chul Noh, Young-Sun Kim, Chang-Sun Hwange, Jong-Il Kim, Yoon Hwan Chang, Seok-Il Hong, Young-Jun Hong, In-Chul Park, Jin Kyung Lee

Biochem Biophys Res Commun. 2013 Aug 2;437(3):463-8.

2. Paris saponin VII from trillium tschonoskii reverses multidrug resistance of adriamycin-resistant MCF-7/ADR cells via P-glycoprotein inhibition and apoptosis augmentation

Li Y, Fan L, Sun Y, Miao X, Zhang F, Meng J, Han J, Zhang D, Zhang R, Yue Z, Mei Q

J Ethnopharmacol. 2014 Jul 3;154(3):728-34.

3. Dehydroepiandrosterone has strong antifibrotic effects and is decreased in idiopathic pulmonary fibrosis

Mendoza-Milla C, Valero Jiménez A, Rangel C, Lozano A, Morales V, Becerril C, Chavira R, Ruiz V, Barrera L, Montaño M, Pardo A, Selman M.

Eur Respir J. 2013 Nov;42(5):1309-21

4. Targeting the proteasome as a promising therapeutic strategy in thyroid cancer

Wunderlich A, Arndt T, Fischer M, Roth S, Ramaswamy A, Greene BH, Brendel C, Hinterseher U, Bartsch DK, Hoffmann S.

J Surg Oncol. 2012 Mar 15;105(4):357-64.

5. Antiproliferation effect of Rosemary (Rosmarinus officinalis) on human ovarian cancer cells in vitro

Tai J, Cheung S, Wu M, Hasman D.

Phytomedicine. 2012 Mar 15;19(5):436-43

6. ECHS1 acts as a novel HBsAg-binding protein enhancing apoptosis through the mitochondrial pathway in HepG2 cells

Xiao CX, Yang XN, Huang QW, Zhang YQ, Lin BY, Liu JJ, Liu YP, Jazag A, Guleng B, Ren JL.

Cancer Lett. 2013 Mar 1;330(1):67-73.

7. Cold atmospheric plasma, a new strategy to induce senescence in melanoma cells

Arndt S, Wacker E, Li YF, Shimizu T, Thomas HM, Morfill GE, Karrer S, Zimmermann JL, Bosserhoff AK.

Exp Dermatol. 2013 Apr;22(4):284-9.

8. Cold atmospheric plasma (CAP) changes gene expression of key molecules of the wound healing machinery and improves wound healing in vitro and in vivo

Arndt S, Unger P, Wacker E, Shimizu T, Heinlin J, Li YF, Thomas HM, Morfill GE, Zimmermann JL, Bosserhoff AK, Karrer S.

PLoS One. 2013 Nov 12;8(11):e79325.

9. Role of Sonic Hedgehog in idiopathic pulmonary fibrosis

Bolaños AL, Milla CM, Lira JC, Ramírez R, Checa M, Barrera L, García-Alvarez J, Carbajal V, Becerril C, Gaxiola M, Pardo A, Selman M.

Am J Physiol Lung Cell Mol Physiol. 2012 Dec 1;303(11):L978-90.

10. SOX2 regulates apoptosis through MAP4K4-Survivin signaling pathway in human lung cancer cells

Chen S, Li X, Lu D, Xu Y, Mou W, Wang L, Chen Y, Liu Y, Li X, Li LY, Liu L, Stupack D, Reisfeld RA, Xiang R, Li N.

Carcinogenesis. 2014 Mar;35(3):613-23.

11. Depletion of the novel protein PHACTR-1 from human endothelial cells abolishes tube formation and induces cell death receptor apoptosis

Jarray R, Allain B, Borriello L, Biard D, Loukaci A, Larghero J, Hadj-Slimane R, Garbay C, Lepelletier Y, Raynaud F.

Biochimie. 2011 Oct;93(10):1668-75.

12. Fibrinogen Alpha Chain Acts as a HBsAg Binding Protein and their Interaction Promotes HepG2 Cell Apoptosis

Li, Ping; Xiao, Li; Li, Ying-Ying; Chen, Xu; Xiao, Chuan-Xing; Liu, Jing-Jing; Yang, Xiao-Ning; Jazag, Amarsanaa; Ren, Jian-Lin; Guleng, Bayasi

Current Proteomics, Volume 11, Number 1, April 2014, pp. 48-54(7)

13. The immunomodulatory drug lenalidomide restores a vitamin D sensitive phenotype to the vitamin D resistant breast cancer cell line MDA-MB-231 through inhibition of BCL-2: potential for breast cancer therapeutics

Brosseau C, Colston K, Dalgleish AG, Galustian C.

Apoptosis. 2012 Feb;17(2):164-73.

14. Antiproliferation activity of Devil's club (Oplopanax horridus) and anticancer agents on human pancreatic cancer multicellular spheroids

Tai J, Cheung SS, Ou D, Warnock GL, Hasman D.

Phytomedicine. 2014 Mar 15;21(4):506-14.

15. Inflammatory and cytotoxic responses of an alveolar-capillary coculture model to silica nanoparticles: comparison with conventional monocultures

Kasper J, Hermanns MI, Bantz C, Maskos M, Stauber R, Pohl C, Unger RE, Kirkpatrick JC.

Part Fibre Toxicol. 2011 Jan 27;8(1):6.

16. Monoclonal Antibody against the Ectodomain of E-Cadherin (DECMA-1) Suppresses Breast Carcinogenesis: Involvement of the HER/PI3K/Akt/mTOR and IAP Pathways

Brouxhon SM, Kyrkanides S, Teng X, Raja V, O'Banion MK, Clarke R, Byers S, Silberfeld A, Tornos C, Ma L.

Clin Cancer Res. 2013 Jun 15;19(12):3234-46.

17. Peptides in common bean fractions inhibit human colorectal cancer cells

Luna Vital DA, González de Mejía E, Dia VP, Loarca-Piña G.

Food Chem. 2014 Aug 15;157:347-55.

18. Notch signaling functions in retinal pericyte survival

Arboleda-Velasquez JF, Primo VA, Graham MJ, James AM, Manent J, D'Amore PA.

Invest Ophthalmol Vis Sci. 2014 Jul 11. pii: IOVS-14-14046.

19. Euphorbia formosana Root Extract Induces Apoptosis by Caspase-Dependent Cell Death via Fas and Mitochondrial Pathway in THP-1 Human Leukemic Cells

Hsieh YJ, Chang CJ, Wan CF, Chen CP, Chiu YH, Leu YL, Peng KC.

Molecules. 2013 Feb 1;18(2):1949-62.

20. Targeting Cadherin-17 Inactivates Ras/Raf/MEK/ERK Signaling and Inhibits Cell Proliferation in Gastric Cancer

Lin Z, Zhang C, Zhang M, Xu D, Fang Y, Zhou Z, Chen X, Qin N, Zhang X.

PLoS One. 2014 Jan 20;9(1):e85296.

21. Cacospongionolide and scalaradial, two marine sesterterpenoids as potent apoptosis-inducing factors in human carcinoma cell lines

22. Antiapoptotic Signaling via MCL1 Confers Resistance to Caspase-3-Mediated Apoptotic Cell Death in the Pregnant Human Uterine Myocyte

Stephenson-Famy A, Marks J, Suresh A, Caritis SN, Simhan H, Jeyasuria P, Condon JC.

Mol Endocrinol. 2012 Feb;26(2):320-30.

23. ABCB5 is a limbal stem cell gene required for corneal development and repair

Ksander BR, Kolovou PE, Wilson BJ, Saab KR, Guo Q, Ma J, McGuire SP, Gregory MS, Vincent WJ, Perez VL, Cruz-Guilloty F, Kao WW, Call MK, Tucker BA, Zhan Q, Murphy GF, Lathrop KL, Alt C, Mortensen LJ, Lin CP, Zieske JD, Frank MH, Frank NY.

Nature. 2014 Jul 17;511(7509):353-7.

24. Targeting of cancer stem cell marker EpCAM by bispecific antibody EpCAMxCD3 inhibits pancreatic carcinoma

Salnikov AV, Groth A, Apel A, Kallifatidis G, Beckermann BM, Khamidjanov A, Ryschich E, Büchler MW, Herr I, Moldenhauer G.

J Cell Mol Med. 2009 Sep;13(9B):4023-33.

25. Luteolin induces apoptosis in multidrug resistant cancer cells without affecting the drug transporter function: Involvement of cell line-specific apoptotic mechanisms

Rao PS, Satelli A, Moridani M, Jenkins M, Rao US.

Int J Cancer. 2012 Jun 1;130(11):2703-14.

26. Fractalkine functions as a chemoattractant for osteoarthritis synovial fibroblasts and stimulates phosphorylation of mitogen-activated protein kinases and Akt

Klosowska K, Volin MV, Huynh N, Chong KK, Halloran MM, Woods JM.

Clin Exp Immunol. 2009 May;156(2):312-9.

27. Role of Apollon in Human Melanoma Resistance to Antitumor Agents That Activate the Intrinsic or the Extrinsic Apoptosis Pathways

Tassi E, Zanon M, Vegetti C, Molla A, Bersani I, Perotti V, Pennati M, Zaffaroni N, Milella M, Ferrone S, Carlo-Stella C, Gianni AM, Mortarini R, Anichini A.

Clin Cancer Res. 2012 Jun 15;18(12):3316-27.

28. Anti-tumor effects of fibroblast growth factor-binding protein (FGF-BP) knockdown in colon carcinoma

Schulze D, Plohmann P, Höbel S, Aigner A.

Mol Cancer. 2011 Nov 23;10:144.

29. Decursin and decursinol angelate from Angelica gigas Nakai induce apoptosis via induction of TRAIL expression on cervical cancer cells

Nam-Hui Yim, Ju Hye Lee, Won-Kyung Cho, Min Chul Yang, Dong Hoon Kwak, Jin Yeul Ma

European Journal of Integrative Medicine Volume 3, Issue 4, December 2011, Pages e299–e307

30. Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, and metastasis

Hendrix A, Maynard D, Pauwels P, Braems G, Denys H, Van den Broecke R, Lambert J, Van Belle S, Cocquyt V, Gespach C, Bracke M, Seabra MC, Gahl WA, De Wever O, Westbroek W.

J Natl Cancer Inst. 2010 Jun 16;102(12):866-80.

31. Glycogen Synthase Kinase-3β, NF-κB Signaling, and Tumorigenesis of Human Osteosarcoma

Tang QL, Xie XB, Wang J, Chen Q, Han AJ, Zou CY, Yin JQ, Liu DW, Liang Y, Zhao ZQ, Yong BC, Zhang RH, Feng QS, Deng WG, Zhu XF, Zhou BP, Zeng YX, Shen JN, Kang T.

J Natl Cancer Inst. 2012 May 16;104(10):749-63.

32. Inducing apoptosis in rolling cancer cells: a combined therapy with aspirin and immobilized TRAIL and E-selectin

Rana K, Reinhart-King CA, King MR.

Mol Pharm. 2012 Aug 6;9(8):2219-27.

33. Cell-intrinsic mechanism involving Siglec-5 associated with divergent outcomes of HIV-1 infection in human and chimpanzee CD4 T cells

Soto PC, Karris MY, Spina CA, Richman DD, Varki A.

J Mol Med (Berl). 2013 Feb;91(2):261-70.

34. Single agent‐and combination treatment with two targeted suicide gene therapy systems is effective in chemoresistant small cell lung cancer cells

aelsen SR, Christensen CL, Sehested M, Cramer F, Poulsen TT, Patterson AV, Poulsen HS.

J Gene Med. 2012 Jul;14(7):445-58.

35. Enhancing In Vivo Survival of Adipose-Derived Stromal Cells Through Bcl-2 Overexpression Using a Minicircle Vector

Hyun J, Grova M, Nejadnik H, Lo D, Morrison S, Montoro D, Chung M, Zimmermann A, Walmsley GG, Lee M, Daldrup-Link H, Wan DC, Longaker MT.

Stem Cells Transl Med. 2013 Sep;2(9):690-702.

36. Combination of Imatinib with CXCR4 antagonist BKT140

Beider K, Darash-Yahana M, Blaier O, Koren-Michowitz M, Abraham M, Wald H, Wald O, Galun E, Eizenberg O, Peled A, Nagler A.

Mol Cancer Ther. 2014 May;13(5):1155-69.

37. Grape polyphenols inhibit Akt/mammalian target of rapamycin signaling and potentiate the effects of gefitinib in breast cancer

Castillo-Pichardo L, Dharmawardhane SF.

Nutr Cancer. 2012;64(7):1058-69.

38. TWEAK affects keratinocyte G2/M growth arrest and induces apoptosis through the translocation of the AIF protein to the nucleus.

39. Locally different endothelial nitric oxide synthase protein levels in ascending aortic aneurysms of bicuspid and tricuspid aortic valve.

40.NFATc2 is a potential therapeutic target in human melanoma.

Perotti V, Baldassari P, Bersani I, Molla A, Vegetti C, Tassi E, Dal Col J, Dolcetti R, Anichini A, Mortarini R.

41. LIM-class homeobox gene Lim1, a novel oncogene in human renal cell carcinoma.

42. Lapatinib, a preventive/therapeutic agent against mammary cancer, suppresses RTK-mediated signaling through multiple signaling pathways.

43. Inhibition of caspase-3 differentially affects vascular smooth muscle cell apoptosis in the concave versus convex aortic sites in ascending aneurysms with a bicuspid aortic valve.

44. CXCR3-B can mediate growth-inhibitory signals in human renal cancer cells by down-regulating the expression of heme oxygenase-1.

45. A proteomic approach to the identification of molecular targets in subsequent apoptosis of HEL cells after diosgenin-induced megakaryocytic differentiation.