eNewsletter for Cardiovascular Biology

 

9¿ù Cardiovascular ¼Ò½Ä !!

-       ¼¼Æ÷ ³» ÁöÁú ÀúÀåÀÇ Á¶Àý LAL ¿¬±¸¸¦ À§ÇÑ Small Molecules

-       Tool of Adipokine study

 

 

 

 

Lipoprotein Uptake Receptors

Lipoprotein Uptake Receptors

 

Circulating LDL, HDL, ±×¸®°í VLDL particles°¡ ¾î¶»°Ô cell ¾ÈÆÆÀ¸·Î À̵¿ÇÒ±î¿ä? LDL R and VLDL R, the LRP family, the LDL R regulator PCSK9, ¹× transporterµéÀÎ ABCA1, SR-BI, and SR-AI/MSR ¸¦ À§ÇÑ ±¤¹üÀ§ÇÑ reagents ¹× assays ¸¦ ÅëÇØ ÀÌ ÇÁ·Î¼¼½º¿¡ ´ëÇØ »õ·ÎÀÌ Á¶¸íÇØ º¾´Ï´Ù.

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Small Molecule Inhibitors of Lysosomal Acid Lipase

Small Molecule Inhibitors of Lysosomal Acid Lipase

 

Lysosomal Acid Lipase (LAL)´Â cholesteryl esters¸¦ ºÐÇØÇÏ°í ¼¼Æ÷ ³» ÁöÁú ÀúÀåÀÇ Á¶Àý¿¡ Áß¿äÇÑ ¿ªÇÒÀ» ÇÕ´Ï´Ù. LipophagyÀÇ dysregulationÀº atherosclerosis ¿Í obesity¿Íµµ °ü·ÃÀÌ ÀÖ½À´Ï´Ù. Tocris¿¡¼­ potent ÇÏ°í selectiveÇÑ LAL inhibitors ¸¦ ã¾Æº¸¼¼¿ä!

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Adiponectin Regulates Triglyceride Levels

Adiponectin Regulates Triglyceride Levels

 

´ç½ÅÀÇ ¿¬±¸¿¡¼­ adipokineÀÌ ¾î¶»°Ô ÀÛ¿ëÇÏ´ÂÁö ¾Ë¾Æº¸¼¼¿ä. R&D Systems´Â antibodies, recombinant proteins, small molecules, ±×¸®°í adiponectinÀÇ ¿Ã¸®°í¸Ó »óŸ¦ ±¸º°ÇÏ´Â Simple Plex¢â assay ¹× Quantikine® ELISA kits ¸¦ º¸À¯ÇÏ°í ÀÖ½À´Ï´Ù.

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GT 949 - A New EAAT2 Modulator from Tocris

Linking High-Fat Diet and Epigenetics in a New Blog

 

°í Áö¹æ½Ä°ú inflammation°úÀÇ °ü·Ã¼º¿¡ ´ëÇØ »õ·Î¿î ¹ß°ßÀÌ ÀÖ¾ú½À´Ï´Ù. Promoter ºÎÀ§¿¡¼­ hypermethylation À» ÅëÇÑ Ankrd26ÀÇ epigenetic downregulationÀº Àå±â°£ °í Áö¹æ½Ä¿¡ ÀÇÇØ À¯µµµÇ°í proinflammatoryÇÑ »óŸ¦ À¯µµÇÏ°Ô µË´Ï´Ù. Read Novus' new blog .

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Fatty Acid Transport Molecules

Fatty Acid Transport Molecules

 

Fatty acids¿Ílipids°¡ ¼¼Æ÷ÀÇ ¼øȯ°ú ³»ºÎ¿¡¼­ ¾î¶»°Ô »ý±â´ÂÁö °ü½ÉÀÖÀ¸½Å°¡¿ä? Fatty acid transfer proteins (FATP), fatty acid binding proteins (FABP), ±×¸®°í Apolipoproteins¿¡ ´ëÇÑ ´ç»çÀÇ reagents ¹× assay¸¦ ÅëÇØ ´ç½ÅÀÇ next experiments¸¦ ÁغñÇÏ½Ç ¼ö ÀÖ½À´Ï´Ù!

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Multi-analyte Immunoassays in 3 Complementary Formats

Multi-analyte Immunoassays in 3 Complementary Formats

 

One experiment¿¡¼­ ¿©·¯ ´Ü¹éÁúÀ» screen! À̸¦ À§ÇØ ¾Æ·¡ÀÇ ´ç»ç°¡ Á¦°øÇÏ´Â tool Áß¿¡ ¼±ÅÃÇØ º¸¼¼¿ä.

Human, mouse, ¶Ç´Â rat adipokinesÀ» À§ÇØ Proteome Profiler¢â antibody arrays, polystyrene or magnetic beads¸¦ »ç¿ëÇÏ´Â ´ç»çÀÇ Luminex® High Performance obesity panel, ¶Ç´Â Simple Plex¢â assays¸¦ ÅëÇØ Çѹø¿¡ 4°³ÀÇ analytes ºÐ¼®.

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Is TREM2 a Novel Microglia Ab Receptor?

Poster of Atherosclerosis Disease Progression

 

¿ì¸®ÀÇ ´«±æÀ» ²ô´Â poster´Â lipid metabolism ¹×transport, LDL oxidation ¹× inflammation, plaque ÁøÇà, plaque ÆÄ¿­, ±×¸®°í Ç÷ÀüÁõÀ» Æ÷ÇÔÇÕ´Ï´Ù. Æ÷½ºÅÍ¿¡ Ç¥½ÃµÈ cells¸¦ ±â¹ÝÀ¸·Î ÇÏ´Â interactive cell markers tool¸¦ ³õÄ¡Áö ¸¶¼¼¿ä. ¹«·á·Î ´Ù¿î·Îµå Çϼ¼¿ä!

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Bio-Techne at Upcoming Meetings

 

British Society for Cardiovascular Research - BSCR
Sheffield, UNITED KINGDOM, September 10-11, 2018

European Antibody Congress 2018
Basel, SWITZERLAND, October 29-31, 2018

Protein and Antibody Engineering Summit
Lisbon, PORTUGAL, November 12-16, 2018

 

 


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Single Cell isolation Smart Aliquotor Single-Cell Isolation Easy to operate with high efficiency Exellent integrity for  PCR and sequencing Single-Cell Cloning High viability and high efficiency Easy to track whole cloning process Rare Cell Isolation From gene edited cells(i.e CRISPR) From clinical samples (i.e.blood) Single-Cell PCR sigle-cell isolation and identification in situ lysis of identified single cell transfer of lysate into PCR tube cDNA synthesis and amplification Operation is very simple Only a common pipette is needed  for use and takes about 15 seconds Excellent cell compatibility It is compatible with isolation of cells that have diameters less than 5¥ìm. High yield and viability One Smart Aliquotor yields about  30 single cells, Which have high viability. Identifiable and selectable Each single can be easily identified and then selected. Features Operation by common pipettes Cell size ¡Â 50¥ìm idiameter Cloning in-situ clonal generation Single-cell yield ~30 cells per device Identification 1 well per second Time in aliquoting ~15 seconds Required cell numbers ¡Ã2cells Minimum aliquot volume 50nL Comparison of Single-Cell Isolation Methods Capability/Specifics Serial Dilution Micro- manipulation Flow Cytometry SMART ALIQUOTOR Simplicity and time consumption Controllability in transfer volume Compatibility in rare cell isolation Compatibility in cell size & shape Throughput Cell viability Cell selectivity Affordability