Targeting senescent cells improves functional recovery after spinal cord injury

Targeting senescent cells improves functional recovery after spinalcord injury

Cell Reports 36, 109334, July 6, 2021

DOI: https://doi.org/10.1016/j.celrep.2021.109334

Persistent senescent cells (SCs) are known to underlie aging-related chronic disorders, but it is now recognized that SCs may be at the center of tissue remodeling events, namely during development or organ repair. In this study, we show that two distinct senescence profiles are induced in the context of a spinal cord injury between the regenerative zebrafish and the scarring mouse. Whereas induced SCs in zebrafish are progressively cleared out, they accumulate over time in mice. Depletion of SCs in spinal-cord-injured mice, with different senolytic drugs, improves locomotor, sensory, and bladder functions. This functional recovery is associated with improved myelin sparing, reduced fibrotic scar, and attenuated inflammation, which correlate with a decreased secretion of pro-fibrotic and pro-inflammatory factors. Targeting SCs is a promising therapeutic strategy not only for spinal cord injuries but potentially for other organs that lack regenerative competence.

논문에서 사용한 Pro-fibrotic / Pro-inflammatory factor 확인 tool, 이 제품입니다!

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Detection of Selected Mouse Cytokines in Balb/3T3 Cell Line Lysate.

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